A SECRET WEAPON FOR BTD

Low concentrations of S1P are chemotactic for osteoclast precursors, while high concentrations inhibit their movement seventy nine. This means that these precursors, which express each S1PR1 and S1PR2, are kept during the vicinity with the bone with the S1P gradient: S1PR2 prevents S1PR1-induced migration of those bone-resorbing cells far from bone